Source: www.nytimes.com --- Thursday, June 28, 2012
Changing its policy on Olympics coverage, NBC Sports will show every event at the London Games live on its Web site. ...
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Saturday, June 30, 2012
TV Sports: NBC Will Show Every Olympic Event Live Online
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Friday, June 29, 2012
Study finds genes associated with hippocampal atrophy
Thursday, June 28, 2012
In a genome-wide association (GWA) study, researchers from Boston University Schools of Medicine (BUSM) and Public Health (BUSPH) have identified several genes which influence degeneration of the hippocampus, the part of the brain most associated with Alzheimer disease (AD). The study, which currently appears online as a Rapid Communication in the Annals of Neurology, demonstrates the efficacy of endophenotypes for broadening the understanding of the genetic basis of and pathways leading to AD.
AD is a progressive neurodegenerative disorder for which there are no prevention methods. Available drugs only marginally affect disease severity and progression, making AD effectively untreatable.
GWA studies using very large samples have increased the number of robust associations to 10 genes, including APOE. However, these genes account for no more than 35 percent of the inherited risk of AD and most of the genetic underpinning of the disorder remains unexplained. According to the researchers, magnetic resonance imaging (MRI) of the brain provides in vivo quantitative measures of neurodegenerative and cerebrovascular brain injury that may represent AD-related changes long before clinical symptoms appear. These measures are more powerful than comparisons of individuals with AD with cognitively healthy persons because they avoid misclassification of normal persons who will develop disease in the future.
BUSM researchers conducted a two-stage GWA study for quantitative measures of hippocampal volume (HV), total cerebral volume (TCV) and white matter hyperintensities (WMH). Brain MRI measures of HV, TCV and WMH were obtained from 981 Caucasian and 419 African-American AD cases and their cognitively normal siblings in the MIRAGE (Multi Institutional Research in Alzheimer's Genetic Epidemiology) Study. In addition, similar MRI measures were obtained from 168 AD cases, 336 individuals with mild cognitive impairment and 188 controls (all Caucasian) in the AD Neuroimaging Initiative (ADNI) Study. The MIRAGE Caucasian families and ADNI subjects were included in the first stage and the MIRAGE African American families were added in stage two. Results from the two Caucasians data sets were combined by meta-analysis.
In stage two, one genetic marker (i.e. single nucleotide polymorphism or SNP) from each of the gene regions that were most significantly associated with AD in the Caucasian data sets was evaluated in the African-American data set.
Novel genome-wide significant associations were observed for HV with SNPs in the APOE, F5/SELP, LHFP, and GCFC2 gene regions. All of these associations were supported by evidence in each data set.
"Our two-stage GWAS identified highly significant associations between a measure of degeneration in the brain region most strongly correlated with AD and several genes in both Caucasian and African American samples containing AD, cognitively impaired and cognitively healthy subjects. One of these associations was with the ?4 variant of APOE which is the most well-established genetic risk factor for AD.
Other associations were demonstrated with markers in F5/SELP, LHFP, and GCFC2, genes not previously implicated in this disease" explained senior author Lindsay Farrer, PhD, chief of biomedical genetics at BUSM. He also noted, "previous studies showed that blood level of P-selectin (the protein encoded by SELP) has been correlated with rate of cognitive decline in AD patients."
Farrer believes it is very likely that the number and specificity of these associations will increase in future studies using larger samples and focused on additional precise structural and functional MRI measures. "These findings will inform experiments designed to increase our understanding of disease-causing mechanism and may lead to new therapeutics targets," added Farrer.
###
Boston University Medical Center: http://www.bmc.org
Thanks to Boston University Medical Center for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
This press release has been viewed 15 time(s).
Source: http://www.labspaces.net/121366/Study_finds_genes_associated_with_hippocampal_atrophy
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Wednesday, June 27, 2012
Breaking News! Aaron Walker SWATted? ? The Daley Gator
Bob Belvedere has the scoop
All we have is Aaron?s Tweet so far [tip of the fedora to?Stacy McCain]:
Aaron Worthing??
@AaronWorthing?6mBREAKING NEWS: tonight I was swatted. More details to come.
More when I get it.
[This post will remain at the top of this column until further notice]
UPDATED at 1935?
The?latest Tweet?from Aaron:
Aaron Worthing??
@AaronWorthingMy wife and I are safe. Will be more details when I can provide it. Wife was very upset dealing with her.
UPDATE at 2011?
-Twitchy is on the story and updating?here.
-From?Joe Brooks:
Brett Kimberlin ally makes blind threat on his website (no safe link available):
?And speaking of fun? I?m told that we have something coming up in the future ourselves that will be killer diller! Hot stuff. Hubba hubba! And I ain?t kidding. I haven?t even been told who it is yet, and already I?m looking forward to it. ?
More details coming soon.
Hmmm.
UPDATE at 2017?
From Patterico:
No joke. It happened around 6 p.m. Eastern. I briefly talked with one of the police officers at the scene, who confirmed that someone had called saying he had shot his wife, and sent officers to Aaron?s address.
He also reports the police has machine guns at the ready.
UPDATE at 2037?
The?latest Tweet?from Dustin:
Dustin ?@Dust92
Spoke with Aaron. He?s OK. He?ll put a post up tonight, but it?ll be a bit.
Expect more Updates.
Bob has more, as does Stacy McCain?It looks as if some miscreants are up to their same old games, and Stacy notes that this comes right on the heels of a legal victory for Walker
At a hearing this morning in Rockville, Maryland, a Montgomery County Circuit Court granted an emergency motion on behalf of attorney/blogger Aaron Walker. The effect of the ruling will permit Walker to resume writing and speaking about convicted terrorist bomber Brett Kimberln.
Judge Nelson W. Rupp Jr. presided over today?s hearing, with attorneyReginald W. Bours III?representing Walker, who did not attend the hearing at Judicial Center in Rockville. In a brief telephone interview, Walker said that Kimberlin filed a counter-motion that did not address the First Amendment legal issues at stake, but rather ?made a bunch of new accusations? against Walker.
It is important to note that Judge Rupp?s ruling only temporarily permits Walker to speak and write about Kimberlin, pending a July 5 hearing in Maryland state appeals court. Walker is appealing a May 29 ruling by Montgomery County District Court Judge C.J. Vaughey that granted a peace order sought by Kimberlin against Walker.
Walker said he plans to file a report on today?s hearing at?his blog, Allergic to Bull. A Virginia attorney, Walker has become the center of national attention since May 17, when he published a 28,000-word blog post entitled, ?How Brett Kimberlin Tried to Frame Me for a Crime (And How You Can Help!).? Walker?s post highlighted Kimberlin?s?long-running efforts harass and intimidate bloggers who had written about Kimberlin?s criminal history.
Go read the rest. The Kimberlin/Rauhauser/SWATting story has ?twist after twist, after twist.
UPDATE! Lee Stranahan at Breitbart has more
Breitbart News contacted the Prince William County, Virginia police department to confirm the swatting. A dispatcher affirmed that police were called to the home of Mr. Walker based on a fraudulent 911 call. The individual did not take the call and could not disclose any details of the call?s content but immediately confirmed that Mr. Walker had been swatted.?
The swatting occurred hours after Walker?s hearing. A judge had modified a previous ruling that prohibited Mr. Walker from exercising his right to free speech.?
Walker told Breitbart News that he was home with his wife this evening at approximately 6:00pm when there was a ?pretty insistent? knock at his door. Walker answered to find about six police cars in the street and two officers taking positions against the wall with M4 rifles. Since he was aware of the previous swattings of Patrick ?Patterico? Frey, Erick Erickson, and Mike Stack, Mr. Walker asked the police if someone had called and claimed he had killed his wife, and police confirmed that that was the case.
In a statement to Breitbart News, Walker said,??This is obviously very upsetting but my wife and I are fine. Whoever did this had the intent to put our lives in danger.?
?
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Tuesday, June 26, 2012
Practical Bodybuilding Tips For Novices | Sports n Recreation Info ...
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Study identifies causes for high rates of allergic reactions in children with food allergies
Study identifies causes for high rates of allergic reactions in children with food allergies
Monday, June 25, 2012A team of researchers from Mount Sinai School of Medicine and four other institutions have found that young children with documented or likely allergies to milk and/or eggs, whose families were instructed on how to avoid these and other foods, still experienced allergic reactions at a rate of almost once per year. Of severe cases, less than a third received epinephrine, a medication used to counter anaphylaxis, a life-threatening allergic condition.
The findings are from an ongoing Consortium of Food Allergy Research (CoFAR) study that has been following more than 500 children with food allergies since infancy. The results of the three-year study appear online in the June 25 issue of Pediatrics.
Nearly 72 percent of the participants experienced a reaction, with 1,171 allergic reactions in total. Allergic reactions were attributed to such factors as a lack of close supervision, misreading ingredient labels, cross-contamination, or errors in food preparation. Participating families had been given written and verbal food avoidance instruction, and written prescriptions for self-injectable epinephrine, beforehand.
"This study reinforces the importance of educating parents and other caregivers of children with food allergy about avoiding allergenic foods and using epinephrine to treat severe food-allergic reactions," said Scott Sicherer, MD, Professor of Pediatrics and Chief of the Division of Allergy and Immunology at Mount Sinai School of Medicine. "We must work harder to thoroughly educate parents about the details of avoidance and when and how to correctly use epinephrine to manage this life-threatening condition."
Approximately 11 percent of the children experienced anaphylaxis, which can include symptoms such as swelling in the throat, asthma, sudden drop in blood pressure, dizziness or fainting. The children's parents or caregivers administered epinephrine in only 30 percent of the cases of children having severe reactions to food. Investigators found children did not receive epinephrine because either the drug was not available, or parents and caregivers were too afraid to administer the drug, or they did not recognize the reaction as severe and waited to see more symptoms.
"We found a significant number of young children received allergenic foods from caregivers other than their parents," said Hugh Sampson, MD, Dean for Translational Biomedical Sciences, Professor of Pediatrics, and Director of the Jaffe Food Allergy Institute at Mount Sinai School of Medicine. "This underscores the need to educate everyone who is responsible for the child, including grandparents, older siblings and teachers."
Dr. Sampson is the lead investigator for COFAR, which is also performing numerous food allergy treatment trials.
The study is taking place at The Mount Sinai Medical Center as well as research hospitals in Baltimore, MD; Denver, CO; Durham, NC; and Little Rock, Ark., with support from The National Institutes of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health. NIAID conducts and supports research?at NIH, throughout the United States, and worldwide?to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses.
###
The Mount Sinai Hospital / Mount Sinai School of Medicine: http://www.mountsinai.org
Thanks to The Mount Sinai Hospital / Mount Sinai School of Medicine for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
This press release has been viewed 49 time(s).
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Monday, June 4, 2012
Rock Energy resources provides April month-end update for gold mining operations in Colorado
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Health care reform forum enlightens area ... - Health and Fitness
Thomas McAuliffe spent well more than 90 minutes Thursday morning giving what he termed a non-partisan overview of the federal health care reform act.
McAuliffe, a policy analyst for the Missouri Foundation of Health, has been crossing the state the past several months outlining the ins and outs of the Patient Protection and Affordable Care Act, which was signed into law by President Obama in March 2010. He told about 40 interested individuals at a Lake Regional Hospital health care forum that his objective was to make the complex health care law easier to understand.
There are approximately 2,500 pages in the law.
?No one, or very few people, know what?s in the law,? he said in his opening remarks. ?It?s hard to read and understand because health care is so complicated.?
He has read it through twice.
An informal show of hands among those attending indicated that most agreed there needs to be some type of health care reform, but a scant few said they are getting what they need from the current health care system.
According to McAuliffe, Americans need health care reform because:
?America has the most expensive care in the world, with some of the poorest outcomes
?Employers cannot afford to offer insurance
?Being without insurance make us ill and poor
?The U.S. economy cannot keep up spending so much on health care/insurance
His presentation included a liturgy of? ?good things? and ?terrible things? about the law, which currently is under scrutiny by the U.S. Supreme Court. A final ruling is expected later this month, and states, insurance companies, health care professionals, individuals and others are awaiting the decision before moving forward.
McAuliffe, who is available to talk to any size group about health care reform, has held about 150 such gatherings in the state including one as small as ?three people in someone?s basement.? Interest in the subject has waned in recent weeks as the country awaits the Supreme Court decision.
He anticipates one of four outcomes from the High Court:
?Overturn the law
?Strike down the individual mandate portion, but uphold the law
?Strike down the individual mandate portion, and pick and choose among segments of the law
?Uphold the law
Under the individual mandate section of the law, individuals would be required to maintain minimum health care coverage each month or pay a penalty. The tax penalty for those without coverage would be $95 in 2014, $325 in 2015, $695 in 2016 and then a flat dollar amount indexed to inflation, capped at 300 percent.
The lists of changes to private health insurance, some of which went into effect in 2010, are long and complicated, McAuliffe noted.
These include:
?Dependents would now be covered up to the age of 26. A dependent is a family member with whom the insurance payer has a relationship.
?There will no longer be any pre-existing condition exclusions
?Beginning in 2014, most people will be expected to carry insurance or pay a fine. A variety of health insurance plans will be available through a newly established exchange or health insurance marketplace. All plans will cover preventative care without co-pays and will not have annual spending limits. Exceptions include individuals with financial hardships or certain religious beliefs
There are an estimated 80 million Americans uninsured and 100 million under insured. The health care reform act hopes to reduce those numbers, according to McAuliffe.
It costs taxpayers between $350 and $2,000 a year to subsidize the uninsured individuals.
?Our system does not work,? he said. ?We pay the highest health care costs in the world and in some cases our morbidity (rate of incidence of disease) is worse than most. We don?t have the best health care in the world except in some components of health care. But if you have a chronic condition, you don?t want to be in this country. We?re bad at preventing and treating morbidity.?
McAuliffe did dispel some misnomers if the law is upheld, including:
?There will be no more co-pay for preventive care as an incentive for people to go to the doctor
?There are no death panels in the law that would determine the fate of individuals based on their health and age.
?Medicare is not running out of money. It is a relatively efficient program
According to the non-partisan Congressional Budget Office, the $940 billion cost of health care reform is estimated to pay for itself. The CBO believes it will also reduce the national debt by $124 billion by 2020. However, rules created for how to implement the law could raise or lower the cost. The investment in preventive care and management of chronic conditions is projected to create even more savings, according to the CBO.
Five Things to Know
?Individuals and small businesses will get more affordable and better insurance in the Exchange
?Most Americans will get some assistance to buy insurance
?Prevention will save money and will focus medicine on outcomes, not treatments
?Much of what this law does isn?t being discussed
?If overturned, the country is back where it started as far as health care reform
For more information, check out www.covermissouri.org, or call 1-800-655-5560.
?
Article source: http://www.lakenewsonline.com/newsnow/x1916929974/Health-care-reform-forum-enlightens-area-residents
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